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| CAS: | 1429757-68-5 | Cat No: | JKN01030 | Purity: | 98% |
Note: All products of the company are for scientific research only, and do not provide products and services for any individual
Product Description
| CAS | 1429757-68-5 | Cat No | JKN01030 | |
| Name | Poziotinib Hydrochloride | |||
| Synonyms | Poziotinib hydrochloride | |||
| Smiles | COC1=C(C=C2C(=C1)N=CN=C2NC3=C(C(=C(C=C3)Cl)Cl)F)OC4CCN(CC4)C(=O)C=C.Cl | |||
| Chemical Name | 1-[4-[4-(3,4-dichloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]prop-2-en-1-one;hydrochloride | |||
| Formula | C23H22Cl3FN4O3 | MWt | 527.8 | |
| Purity | 98% | Storage | Store at 4--8℃ | |
| Description | Poziotinib Hydrochloride is the hydrochloride salt form of poziotinib, an orally bioavailable, quinazoline-based, irreversible pan-epidermal growth factor receptor (EGFR or HER) inhibitor, with potential antineoplastic activity. Upon oral administration, poziotinib inhibits EGFR (HER1 or ErbB1), HER2 and HER4, thereby inhibiting proliferation of tumor cells in which these receptors are overexpressed and/or mutated. EGFRs, cell surface receptor tyrosine kinases upregulated or mutated in a variety of cancer cell types, play key roles in cellular proliferation and survival. | |||
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