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| CAS: | 1056634-68-4 | Cat No: | JKN00813 | Purity: | 98% |
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Product Description
| CAS | 1056634-68-4 | Cat No | JKN00813 | |
| Name | Momelotinib | |||
| Synonyms | CYT-387 | |||
| Smiles | C1COCCN1C2=CC=C(C=C2)NC3=NC=CC(=N3)C4=CC=C(C=C4)C(=O)NCC#N | |||
| Chemical Name | N-(cyanomethyl)-4-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]benzamide | |||
| Formula | C23H22N6O2 | MWt | 414.5 | |
| Purity | 98% | Storage | Store at 4--8℃ | |
| Description | Momelotinib is a benzamide obtained by formal condensation of the carboxy group of 4-{2-[4-(morpholin-4-yl)anilino]pyrimidin-4-yl}benzoic acid with the primary amino group of aminoacetonitrile. It is an ATP-competitive JAK1/JAK2 inhibitor with IC50 of 11 nM and 18 nM, respectively. Used for the treatment of patients with intermediate- or high-risk myelofibrosis. It has a role as an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor, an antineoplastic agent, an anti-anaemic agent and an apoptosis inducer. It is an aminopyrimidine, a member of morpholines, a secondary amino compound, a tertiary amino compound, a member of benzamides and a nitrile. | |||
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