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| CAS: | 1613220-15-7 | Cat No: | JKN00839 | Purity: | 98% |
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Product Description
| CAS | 1613220-15-7 | Cat No | JKN00839 | |
| Name | MK4827 | |||
| Synonyms | Niraparib tosylate monohydrate | |||
| Smiles | CC1=CC=C(C=C1)S(=O)(=O)O.C1C[C@H](CNC1)C2=CC=C(C=C2)N3C=C4C=CC=C(C4=N3)C(=O)N.O | |||
| Chemical Name | 4-methylbenzenesulfonic acid;2-[4-[(3S)-piperidin-3-yl]phenyl]indazole-7-carboxamide;hydrate | |||
| Formula | C26H30N4O5S | MWt | 510.6 | |
| Purity | 98% | Storage | Store at 4--8℃ | |
| Description | Niraparib Tosylate Monohydrate is an orally bioavailable, hydrated, tosylate salt form of niraparib, an inhibitor of poly (ADP-ribose) polymerase (PARP) types 1 and 2 (PARP-1 and -2), with antineoplastic activity. Upon administration, niraparib binds to and inhibits the activity of PARP-1 and -2, thereby inhibiting PARP-1 and -2-mediated DNA repair, enhancing the accumulation of DNA strand breaks, promoting genomic instability and resulting in apoptosis. The PARP family of proteins catalyzes post-translational ADP-ribosylation of nuclear proteins and is activated by single-strand DNA (ssDNA) breaks. | |||
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