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| CAS: | 940290-58-4 | Cat No: | JKN01110 | Purity: | 98% |
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Product Description
| CAS | 940290-58-4 | Cat No | JKN01110 | |
| Name | UK-122 | |||
| Synonyms | UK-122 | |||
| Smiles | N=C(C1=CC=C(/C=C2N=C(C3=CC=CC=C3)OC/2=O)C=C1)N | |||
| Chemical Name | (E)-4-((5-oxo-2-phenyloxazol-4(5H)-ylidene)methyl)benzimidamide | |||
| Formula | C17H13N3O2 | MWt | 291.30 | |
| Purity | 98% | Storage | Store at 4--8℃ | |
| Description | UK-122, also known as uPA Inhibitor II, is a potent and selective uPA inhibitor (Ki = 20 nM). The IC(50) of UK122 in a cell-free indirect uPA assay is 0.2 micromol/L. UK-122 also showed no or little inhibition of other serine proteases such as thrombin, trypsin, plasmin, and the tissue-type plasminogen activator, indicating its high specificity against uPA. Moreover, UK122 showed little cytotoxicity against CFPAC-1 cells (IC(50) >100 micromol/L) but significantly inhibited the migration and invasion of this pancreatic cancer cell line. UK122 could potentially be developed as a new anticancer agent that prevents the invasion and metastasis of pancreatic cancer. Chemical Structure UK-122 CAS# 940290-58-4 Theoretical Analysis | |||
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