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| CAS: | 2375421-09-1 | Cat No: | JKN00193 | Purity: | 98% |
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Product Description
| CAS | 2375421-09-1 | Cat No | JKN00193 | |
| Name | SR-717 lithium | |||
| Synonyms | SR717lithium | |||
| Smiles | O=C([O-])C1=CC(F)=C(F)C=C1NC(C2=NN=C(N3C=CN=C3)C=C2)=O.[Li+] | |||
| Chemical Name | lithium 2-(6-(1H-imidazol-1-yl)pyridazine-3-carboxamido)-4,5-difluorobenzoate | |||
| Formula | C15H8F2LiN5O3 | MWt | 351.198 | |
| Purity | 98% | Storage | Store at 4--8℃ | |
| Description | SR-717 is an agonist of stimulator of interferon genes STING for treating cancer. SR-717 demonstrates broad interspecies and interallelic specificity. SR-717 functions as a direct cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic that induces the same "closed" conformation of STING. SR-717 displayed antitumor activity; promoted the activation of CD8+ T, natural killer, and dendritic cells in relevant tissues; and facilitated antigen cross-priming. SR-717 also induced the expression of clinically relevant targets, including programmed cell death 1 ligand 1 (PD-L1), in a STING-dependent manner. | |||
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