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| CAS: | 211110-63-3 | Cat No: | JKN00323 | Purity: | 98% |
Note: All products of the company are for scientific research only, and do not provide products and services for any individual
Product Description
| CAS | 211110-63-3 | Cat No | JKN00323 | |
| Name | Sobetirome | |||
| Synonyms | GC1 | |||
| Smiles | O=C(O)COC1=CC(C)=C(CC2=CC=C(O)C(C(C)C)=C2)C(C)=C1 | |||
| Chemical Name | 2-(4-(4-hydroxy-3-isopropylbenzyl)-3,5-dimethylphenoxy)acetic acid | |||
| Formula | C20H24O4 | MWt | 328.410 | |
| Purity | 98% | Storage | Store at 4--8℃ | |
| Description | Sobetirome, also known as GC-1 and QRX-431, is a thyroid hormone receptor β (TRβ) agonist. Sobetirome inhibits proliferation but induces differentiation and TRβ mRNA expression in mouse and rat osteoblast-like cells. Sobetirome selectively binds to and activates TRβ over TRα and this receptor selectivity led to the hypothesis that sobetirome would lower cholesterol through activation of liver TRβ without stimulating cardiac function through TRα activation in the heart. The tissue selective thyromimetic properties of sobetirome have been demonstrated in numerous animal models, which led to its clinical development as a novel cholesterol-lowering agent. | |||
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