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| CAS: | 130495-35-1 | Cat No: | JKN00328 | Purity: | 98% |
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Product Description
| CAS | 130495-35-1 | Cat No | JKN00328 | |
| Name | SKF-96365 HCl | |||
| Synonyms | SKF96365 | |||
| Smiles | COC1=CC=C(CCCOC(C2=CC=C(OC)C=C2)CN3C=CN=C3)C=C1.[H]Cl | |||
| Chemical Name | 1-(2-(4-methoxyphenyl)-2-(3-(4-methoxyphenyl)propoxy)ethyl)-1H-imidazole hydrochloride | |||
| Formula | C22H27ClN2O3 | MWt | 402.920 | |
| Purity | 98% | Storage | Store at 4--8℃ | |
| Description | SKF-96365 is a selective TRPC channel blocker. SKF-96365 activates cytoprotective autophagy to delay apoptosis in colorectal cancer cells through inhibition of the calcium/CaMKIIγ/AKT-mediated pathway. SKF-96365 strongly inhibits voltage-gated sodium current in rat ventricular myocytes. SKF 96365 inhibits glioblastoma cell growth by enhancing reverse mode of the Na(+) /Ca(2+) exchanger and increasing intracellular Ca(2+). SKF-96365 attenuates toxin-induced neuronal injury through opposite regulatory effects on Homer1a and Homer1b/c in cultured rat mesencephalic cells. | |||
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