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| CAS: | 1309357-15-0 | Cat No: | JKN03645 | Purity: | 98% |
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Product Description
| CAS | 1309357-15-0 | Cat No | JKN03645 | |
| Name | Silmitasertib Sodium | |||
| Synonyms | Silmitasertib sodium | |||
| Smiles | C1=CC(=CC(=C1)Cl)NC2=NC3=C(C=CC(=C3)C(=O)[O-])C4=C2C=CN=C4.[Na+] | |||
| Chemical Name | sodium;5-(3-chloroanilino)benzo[c][2,6]naphthyridine-8-carboxylate | |||
| Formula | C19H11ClN3NaO2 | MWt | 371.7 | |
| Purity | 98% | Storage | Store at 4--8℃ | |
| Description | Silmitasertib Sodium is the sodium salt form of silmitasertib, an orally bioavailable small-molecule inhibitor of the enzyme casein kinase II (CK2), with potential antineoplastic, anti-viral and immunomodulatory activities. Upon oral administration, silmitasertib selectively binds to and inhibits the activity of CK2. This may inhibit proliferation of CK2-expressing tumor cells, and may also inhibit the replication of severe acute respiratory syndrome coronavirus-2 (SARS-COV-2). In addition, this may restore normal host cell cytokine regulation, prevent cytokine storm and suppress the hyperactivation of the innate immune system. CK2, a protein kinase often overexpressed in a variety of cancer cell types, appears to be correlated with malignant transformation, tumor growth and survival. CK2 regulates a diverse array of pro-survival cellular processes including epidermal growth factor receptor (EGFR) signaling, PI3K/AKT/mTOR signaling, hedgehog (Hh) signaling, Hsp90 machinery, hypoxia, and interleukin (IL)-6 expression. CK2 also regulates the activity of XRCC1 and MDC1, two mediator/adaptor proteins that are essential for DNA repair. CK2 is upregulated by SARS-COV-2 and is associated with SARS-COV-2 viral replication and the development of cytokine storm. | |||
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