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| CAS: | 2443816-41-7 | Cat No: | JKN01125 | Purity: | 98% |
Note: All products of the company are for scientific research only, and do not provide products and services for any individual
Product Description
| CAS | 2443816-41-7 | Cat No | JKN01125 | |
| Name | Sel-120 | |||
| Synonyms | SEL-120 | |||
| Smiles | CC1=C2C3=C(CCCN3C(=N2)N4CCNCC4)C(=C1Br)Br.Cl | |||
| Chemical Name | 6,7-dibromo-5-methyl-2-piperazin-1-yl-1,3-diazatricyclo[6.3.1.04,12]dodeca-2,4,6,8(12)-tetraene;hydrochloride | |||
| Formula | C15H19Br2ClN4 | MWt | 450.6 | |
| Purity | 98% | Storage | Store at 4--8℃ | |
| Description | CDK8/19 Inhibitor RVU120 is an orally bioavailable inhibitor of cyclin-dependent kinases 8 and 19 (CDK8/19), with potential antineoplastic and chemoprotective activities. Upon oral administration, CDK8/19 inhibitor RVU120 targets, binds to and inhibits the activity of CDK8/19, which prevents activation of CDK8/19-mediated oncogenic signaling pathways, blocks selective transcription of various tumor-promoting genes, and inhibits proliferation of CDK8/19-overexpressing tumor cells. CDK8/19, serine/threonine kinases involved in the regulation of the cell cycle, are overexpressed in certain cancer cell types and play key roles in tumor cell proliferation. | |||
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