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| CAS: | 949912-58-7 | Cat No: | JKN00185 | Purity: | 98% |
Note: All products of the company are for scientific research only, and do not provide products and services for any individual
Product Description
| CAS | 949912-58-7 | Cat No | JKN00185 | |
| Name | Remodelin | |||
| Synonyms | Remodelin | |||
| Smiles | N#CC1=CC=C(C2=CSC(N/N=C3CCCC\3)=N2)C=C1 | |||
| Chemical Name | 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile | |||
| Formula | C15H14N4S | MWt | 282.36 | |
| Purity | 98% | Storage | Store at 4--8℃ | |
| Description | Remodelin is an inhibitor of N-acetyltransferase 10 (NAT10), which acetylates both histones and microtubules. It improves nuclear shape in HGPS (Hutchinson-Gilford progeria syndrome) cells and lamin A/C depleted cells. Remodelin improves nuclear architecture, chromatin organization, and survival of both cells lacking lamin A and cells from patients with progeria. reported to reverse the effect of cancer conditions such as epithelial to mesenchymal transition, hypoxia, and drug resistance. | |||
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