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| CAS: | 1038915-60-4 | Cat No: | JKN00181 | Purity: | 98% |
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Product Description
| CAS | 1038915-60-4 | Cat No | JKN00181 | |
| Name | Niraparib free base | |||
| Synonyms | MK4827 | |||
| Smiles | O=C(C1=CC=CC2=CN(C3=CC=C([C@H]4CNCCC4)C=C3)N=C12)N | |||
| Chemical Name | (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide | |||
| Formula | C19H20N4O | MWt | 320.4 | |
| Purity | 98% | Storage | Store at 4--8℃ | |
| Description | Niraparib, also known as MK4827, is an orally active, potent and selective poly(ADP-Ribose) polymerase (PARP) inhibitor that radiosensitizes human lung and breast cancer cells. Niraparib inhibits PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM respectively. Niraparib is currently in Phase 3 clinical trials for ovarian cancer and BRCA+ breast cancer. | |||
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