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| CAS: | 698387-09-6 | Cat No: | JKN00067 | Purity: | 98% |
Note: All products of the company are for scientific research only, and do not provide products and services for any individual
Product Description
| CAS | 698387-09-6 | Cat No | JKN00067 | |
| Name | Neratinib | |||
| Synonyms | HKI-272 | |||
| Smiles | O=C(NC1=C(OCC)C=C2N=CC(C#N)=C(NC3=CC=C(OCC4=NC=CC=C4)C(Cl)=C3)C2=C1)/C=C/CN(C)C | |||
| Chemical Name | (2E)-N-[4-[[3-chloro-4-[(pyridin-2-yl)methoxy]phenyl]amino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide | |||
| Formula | C30H29ClN6O3 | MWt | 557.040 | |
| Purity | 98% | Storage | Store at 4--8℃ | |
| Description | Neratinib, also known as HKI-272 or PB272, is an orally available, irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Neratinib binds to the HER-2 receptor irreversibly, thereby reducing autophosphorylation in cells, apparently by targeting a cysteine residue in the ATP-binding pocket of the receptor. | |||
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