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MRTX-1257

CAS:

2206736-04-9

Cat No:

JKN00052

Purity:

98%

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Note: All products of the company are for scientific research only, and do not provide products and services for any individual

Product Description

CAS	2206736-04-9	Cat No	JKN00052
Name	MRTX-1257
Synonyms	MRTX-1257
Smiles	CC1=C2C(=CC=C1)C=CC=C2N3CCC4=C(C3)N=C(N=C4N5CCN([C@H](C5)CC#N)C(=O)C=C)OC[C@@H]6CCCN6C
Chemical Name	(2S)-1-(1-Oxo-2-propen-1-yl)-4-[5,6,7,8-tetrahydro-7-(8-methyl-1-naphthalenyl)-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-2-piperazineacetonitrile
Formula	C33H39N7O2	MWt	565.71
Purity	98%	Storage	Store at 4--8℃
Description	MRTX-1257 is a novel, potent, selective, orally bioavailable and covalent / irreversible inhibitor of KRAS G12C with an IC50 of 900 pM for KRAS dependent ERK phosphorylation in H358 cells.

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