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MK-1084

CAS: 2641216-67-1 Cat No: JKN03248 Purity: 98%

Note: All products of the company are for scientific research only, and do not provide products and services for any individual

MK-1084 Powder for KRAS G12C Research

MK-1084 Powder Supplier — CAS 2641216-67-1

JKN Biochem supplies MK-1084 powder, also known as Calderasib, for KRAS G12C signaling pathway research and oncology drug discovery programs. With 98% purity, defined chemical identity, documentation support, and custom synthesis capability, JKN Biochem helps research laboratories and pharmaceutical teams source MK-1084 efficiently from research-scale quantities to larger project-based requirements.

Purity        98%
CAS Number        2641216-67-1
Catalog No.        JKN03248

Why Choose JKN Biochem as Your MK-1084 Powder Supplier?

MK-1084 is a high-value KRAS G12C research compound, and buyers usually need more than a product listing. JKN Biochem supports compound sourcing, analytical documentation, custom synthesis, scale-up evaluation, and global shipment coordination for pharmaceutical and biochemical research customers.

  • Focused product portfolio: APIs, pharmaceutical intermediates, small-molecule inhibitors, electronic materials, organic synthesis building blocks, and drug impurity reference standards.

  • Flexible supply capability: research-scale, gram-scale, kilogram-scale, and project-based custom production support.

  • Technical manufacturing network: R&D center, pilot plant, production base, stable cooperative factories, and experienced international trade support.

  • Quality documentation support: COA, SDS, HPLC, NMR, MS, and other analytical documents can be discussed according to batch and order requirements.

  • Custom synthesis service: structure-based inquiry, CAS-based sourcing, fine chemical synthesis, route evaluation, and scale-up coordination.

Product Snapshot

Product NameMK-1084
SynonymsCalderasib; MK1084
CAS No.2641216-67-1
Catalog No.JKN03248
Purity98%
FormulaC32H31ClF2N6O4
Molecular Weight637.1
StorageStore at 4–8℃

Technical Data

The following information helps procurement, R&D, and analytical teams verify the product identity of MK-1084 powder before quotation, purchase, or documentation review.

Chemical Name19-chloro-22-(2,5-dimethyl-4-prop-2-enoylpiperazin-1-yl)-13,16-difluoro-3-propan-2-yl-8,11-dioxa-1,4,23,26-tetrazapentacyclo[16.6.2.02,7.012,17.021,25]hexacosa-2(7),3,5,12,14,16,18,20,22,25-decaen-24-one
SMILESCC1CN(C(CN1C(=O)C=C)C)C2=NC(=O)N3C4=C(C=CN=C4C(C)C)OCCOC5=C(C=CC(=C5C6=C(C=C2C3=N6)Cl)F)F
Research CategoryKRAS signaling pathway; KRAS G12C inhibitor; oncology research compound
AppearancePowder or solid; final appearance should be confirmed by batch COA.
Recommended UseFor scientific research and chemical synthesis use only. Not for human, diagnostic, therapeutic, food, or veterinary use.

Mechanism & Research Relevance

MK-1084 is a selective KRAS G12C inhibitor used in studies of mutant KRAS-driven signaling. KRAS G12C is a clinically important oncogenic mutation involved in abnormal downstream pathway activation, including RAF-MEK-ERK signaling, which is closely associated with tumor cell growth and survival.

As a KRAS G12C research signaling pathway compound, MK-1084 powder is relevant for oncology pathway research, covalent inhibitor evaluation, cancer cell signaling studies, combination strategy exploration, and medicinal chemistry programs focused on RAS pathway modulation.

Research Applications

  • KRAS G12C signaling pathway research

  • RAS-RAF-MAPK-ERK pathway studies

  • Oncology drug discovery and target validation

  • Small-molecule inhibitor screening

  • Medicinal chemistry and SAR comparison projects

  • Analytical method development and reference compound evaluation

  • Custom synthesis and scale-up feasibility studies

Quality & Documentation Support

When selecting an MK-1084 powder supplier, quality traceability and documentation are key decision factors. JKN Biochem can provide or discuss batch-related documents according to project requirements, helping researchers confirm purity, identity, handling, and storage information before use.

COA Support        Certificate of Analysis available according to batch status and order requirements.
Analytical Data        HPLC, NMR, MS, and related test data can be discussed before quotation or shipment.
SDS & Handling        Safety and handling information can be provided to support laboratory compliance review.

Packaging, Storage & Handling

  • Storage: Store MK-1084 powder at 4–8℃ unless the batch label or COA specifies otherwise.

  • Packaging: Milligram, gram, and larger custom package sizes can be discussed according to project needs.

  • Handling: Handle in a qualified laboratory environment using appropriate PPE and institutional safety procedures.

  • Stability: Keep containers tightly sealed and protect from unsuitable temperature, moisture, and contamination.

  • Documentation: Request COA, SDS, and analytical data before shipment when required by your internal QA process.

Supply Options for MK-1084 Powder

JKN Biochem supports both direct inquiry and custom synthesis evaluation for MK-1084 and related KRAS pathway compounds. Please provide quantity, purity, timeline, and documentation requirements for accurate quotation.

  • Research-scale MK-1084 powder inquiry

  • Bulk inquiry for larger project requirements

  • Custom synthesis and route evaluation

  • Purity optimization and analytical method discussion

  • Gram-to-kilogram supply coordination

  • International shipping and export documentation support

How JKN Biochem Helps You Reduce Sourcing Risk

MK-1084 is a specialized research compound. A reliable supplier should provide more than a catalog name: buyers need chemical identity, purity confirmation, documentation, realistic lead time, secure packaging, and communication throughout the order process.

Verified Inquiry        CAS number, structure, purity, and requested quantity are reviewed before quotation.
Documented Quality        Batch-related COA and analytical information can support internal research documentation.
Scalable Supply        From small research orders to custom synthesis and larger project supply evaluation.

Frequently Asked Questions

What is MK-1084?

MK-1084, also known as Calderasib, is a selective KRAS G12C inhibitor used for scientific research in oncology signaling pathways and small-molecule inhibitor studies.

What is the CAS number of MK-1084?

The CAS number of MK-1084 is 2641216-67-1.

What purity does JKN Biochem supply?

JKN Biochem lists MK-1084 with 98% purity. Please confirm final batch purity, test method, and analytical data with the COA before use.

Can JKN Biochem provide bulk MK-1084 powder?

Yes. JKN Biochem can evaluate bulk inquiry and custom synthesis requirements based on requested quantity, purity, analytical documentation, and delivery timeline.

Is MK-1084 supplied for human use?

No. MK-1084 supplied by JKN Biochem is for scientific research and chemical synthesis use only. It is not intended for human, diagnostic, therapeutic, food, or veterinary use.

Request MK-1084 Powder Quote

Looking for an MK-1084 powder supplier? Send your required quantity, purity expectation, documentation needs, destination country, and target delivery schedule. JKN Biochem will evaluate availability, custom synthesis feasibility, lead time, packaging, and quotation details for MK-1084 CAS 2641216-67-1.

Send Inquiry Now

Note: All products are for scientific research only and are not provided to individuals for personal use.

Product Description

CAS 2641216-67-1 Cat No JKN03248
Name MK-1084
Synonyms MK-1084
Smiles CC1CN(C(CN1C(=O)C=C)C)C2=NC(=O)N3C4=C(C=CN=C4C(C)C)OCCOC5=C(C=CC(=C5C6=C(C=C2C3=N6)Cl)F)F
Chemical Name 19-chloro-22-(2,5-dimethyl-4-prop-2-enoylpiperazin-1-yl)-13,16-difluoro-3-propan-2-yl-8,11-dioxa-1,4,23,26-tetrazapentacyclo[16.6.2.02,7.012,17.021,25]hexacosa-2(7),3,5,12,14,16,18,20,22,25-decaen-24-one
Formula C32H31ClF2N6O4 MWt 637.1
Purity 98% Storage Store at 4--8℃
Description MK-1084 is a selective KRAS G12C inhibitor currently in Phase I clinical trials

Product Documents

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