Pharmaceutical intermediates

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MGD-28

CAS: 2991818-13-2 Cat No: JKN03241 Purity: 98%

Note: All products of the company are for scientific research only, and do not provide products and services for any individual

Product Description

CAS 2991818-13-2 Cat No JKN03241
Name MGD-28
Synonyms MGD-28
Smiles CN1CC2=C(C=CC=C2NCC3=CC=C(C=C3)CN4CCN(CC4)C5=CC(=C(C=C5)C#N)F)C(=O)N1C6CCC(=O)NC6=O
Chemical Name 4-[4-[[4-[[[2-(2,6-dioxopiperidin-3-yl)-3-methyl-1-oxo-4H-phthalazin-5-yl]amino]methyl]phenyl]methyl]piperazin-1-yl]-2-fluorobenzonitrile
Formula C33H34FN7O3 MWt 595.7
Purity 98% Storage Store at 4--8℃
Description MGD-28 is an orally active, Cereblon (CRBN)-dependent IKAROS protein degrader that degrades IKZF1 (DC50=3.8 nM), IKZF2 (DC50=56.3 nM), and IKZF3 (DC50=7.1 nM) in a dose-dependent manner.

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