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CAS: | 2991818-13-2 | Cat No: | JKN03241 | Purity: | 98% |
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Product Description
CAS | 2991818-13-2 | Cat No | JKN03241 | |
Name | MGD-28 | |||
Synonyms | MGD-28 | |||
Smiles | CN1CC2=C(C=CC=C2NCC3=CC=C(C=C3)CN4CCN(CC4)C5=CC(=C(C=C5)C#N)F)C(=O)N1C6CCC(=O)NC6=O | |||
Chemical Name | 4-[4-[[4-[[[2-(2,6-dioxopiperidin-3-yl)-3-methyl-1-oxo-4H-phthalazin-5-yl]amino]methyl]phenyl]methyl]piperazin-1-yl]-2-fluorobenzonitrile | |||
Formula | C33H34FN7O3 | MWt | 595.7 | |
Purity | 98% | Storage | Store at 4--8℃ | |
Description | MGD-28 is an orally active, Cereblon (CRBN)-dependent IKAROS protein degrader that degrades IKZF1 (DC50=3.8 nM), IKZF2 (DC50=56.3 nM), and IKZF3 (DC50=7.1 nM) in a dose-dependent manner. |
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