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JQKD82 HCl

CAS:

2863676-87-1

Cat No:

JKN00308

Purity:

98%

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Product Description

CAS	2863676-87-1	Cat No	JKN00308
Name	JQKD82 HCl
Synonyms	JQKD82
Smiles	O=C(OC1=CC=C(OC(C)C)C=C1OC(C)C)C2=CC=NC(CNCC(N(CCN(C)C)CC)=O)=C2.[H]Cl.[H]Cl.[H]Cl
Chemical Name	2,4-diisopropoxyphenyl 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinate trihydrochloride
Formula	C27H43Cl3N4O5	MWt	610.010
Purity	98%	Storage	Store at 4--8℃
Description	JQKD82, also known as PCK82, is a cell-permeable and selective KDM5 inhibitor (MM.1S cells, IC50 = 0.42 uM). JQKD82 increases histone H3K4me3 but paradoxically inhibits downstream MYC-driven transcriptional output in vitro and in vivo. JQKD82 is a useful tool compound to block KDM5A function as a potential therapeutic strategy for MM. QKD82 is a more stable ester of KDM5-C49 that is able to deliver the active molecule KDM5-C49 to cells more efficiently

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