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| CAS: | 2169223-48-5 | Cat No: | JKN00279 | Purity: | 98% |
Note: All products of the company are for scientific research only, and do not provide products and services for any individual
Product Description
| CAS | 2169223-48-5 | Cat No | JKN00279 | |
| Name | JAB-3068 | |||
| Synonyms | JAB3068 | |||
| Smiles | CC(N1CC(F)(C2=C1C=CC=C2SC3=NC=C(N=C3N)N4CCC5([C@@H](COC5)N)CC4)F)=O | |||
| Chemical Name | (S)-1-(4-((3-amino-5-(4-amino-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)-3,3-difluoroindolin-1-yl)ethan-1-one | |||
| Formula | C22H26F2N6O2S | MWt | 476.547 | |
| Purity | 98% | Storage | Store at 4--8℃ | |
| Description | JAB-3068, also known as HMN23485, SHP2-IN-6, is a potent SHP2 inhibitor. JAB-3068 targets, binds to and inhibits the activity of SHP2. This prevents SHP2-mediated signaling, inhibits MAPK signaling and prevents growth of SHP2-expressing tumor cells. SHP2, an oncoprotein overexpressed in a variety of cancer cell types, regulates cell survival, differentiation and proliferation through activation of the Ras-Raf-MEK-ERK signaling pathway. The Ras-MAPK pathway is often hyperactivated in cancer cells due to specific mutations and rearrangements and are dependent on SHP2 for their oncogenic signaling. SHP2 also regulates programmed cell death 1 (PD-1)-mediated signal transduction and is involved in immune checkpoint modulation. | |||
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