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| CAS: | 1646321-63-2 | Cat No: | JKN00081 | Purity: | 98% |
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Product Description
| CAS | 1646321-63-2 | Cat No | JKN00081 | |
| Name | Iptacopan HCl | |||
| Synonyms | LNP023 | |||
| Smiles | O=C(O)C1=CC=C([C@H]2N(CC3=C(OC)C=C(C)C4=C3C=CN4)CC[C@H](OCC)C2)C=C1.[H]Cl | |||
| Chemical Name | 4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic acid hydrochloride | |||
| Formula | C25H31ClN2O4 | MWt | 458.980 | |
| Purity | 98% | Storage | Store at 4--8℃ | |
| Description | Iptacopan, also known as LNP023, is a complement Factor B Inhibitor (IC50=10 nM). LNP023 improves LN in MRL/lpr mice. The mechanism is as follows: LNP023 binds to CFB to inhibit the activation of the alternative complement pathway. LNP023 treatment for LN may also play a role in regulating the protein expression of AKT, TNF-α, and STST3. LNP023 showed low clearance and high bioavailability (62.2%). Furthermore, four minor metabolites from rat plasma were detected and identified by LC combined with high-resolution mass spectrometry. The metabolic pathways were O-deethylation (M1), hydroxylation (M4), oxidation (M3), and acyl-glucuronidation (M2). | |||
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