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CAS: | 873225-46-8 | Cat No: | JKN00183 | Purity: | 98% |
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Product Description
CAS | 873225-46-8 | Cat No | JKN00183 | |
Name | IKK-16 | |||
Synonyms | IKK16 | |||
Smiles | O=C(C1=CC=C(NC2=NC=CC(C3=CC4=CC=CC=C4S3)=N2)C=C1)N5CCC(N6CCCC6)CC5 | |||
Chemical Name | (4-((4-(benzo[b]thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone | |||
Formula | C28H29N5OS | MWt | 483.63 | |
Purity | 98% | Storage | Store at 4--8℃ | |
Description | IKK-16 is a potent and slective inhibitor of IκB kinase (IKK) (IC50 values are 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively). KK-16 inhibits TNFα-stimulated expression of the adhesion molecules E-selectin, ICAM-1, and VCAM-1 in HUVEC cells. |
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