Pharmaceutical intermediates

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IKK-16

CAS: 873225-46-8 Cat No: JKN00183 Purity: 98%

Note: All products of the company are for scientific research only, and do not provide products and services for any individual

Product Description

CAS 873225-46-8 Cat No JKN00183
Name IKK-16
Synonyms IKK16
Smiles O=C(C1=CC=C(NC2=NC=CC(C3=CC4=CC=CC=C4S3)=N2)C=C1)N5CCC(N6CCCC6)CC5
Chemical Name (4-((4-(benzo[b]thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone
Formula C28H29N5OS MWt 483.63
Purity 98% Storage Store at 4--8℃
Description IKK-16 is a potent and slective inhibitor of IκB kinase (IKK) (IC50 values are 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively). KK-16 inhibits TNFα-stimulated expression of the adhesion molecules E-selectin, ICAM-1, and VCAM-1 in HUVEC cells.

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