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| CAS: | 2647442-13-3 | Cat No: | JKN00253 | Purity: | 98% |
Note: All products of the company are for scientific research only, and do not provide products and services for any individual
Product Description
| CAS | 2647442-13-3 | Cat No | JKN00253 | |
| Name | GS621763 | |||
| Synonyms | GS-621763 | |||
| Smiles | O=C(C(C)C)O[C@@H]1[C@@H](COC(C(C)C)=O)O[C@](C2=CC=C3N2N=CN=C3N)(C#N)[C@@H]1OC(C(C)C)=O | |||
| Chemical Name | (2R,3R,4R,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2-cyano-5-((isobutyryloxy)methyl)tetrahydrofuran-3,4-diyl bis(2-methylpropanoate) | |||
| Formula | C24H31N5O7 | MWt | 501.540 | |
| Purity | 98% | Storage | Store at 4--8℃ | |
| Description | GS621763 is an oral nucleoside analog of Remdesivir against SARS-CoV-2 pathogenesis in mice. GS-621763, an orally bioavailable prodrug of GS-441524, the parental nucleoside of Remdesivir, which targets the highly conserved RNA-dependent RNA polymerase. GS-621763 exhibited significant antiviral activity in lung cell lines and two different human primary lung cell culture systems. The dose-proportional pharmacokinetic profile observed after oral administration of GS-621763 translated to dose-dependent antiviral activity in mice infected with SARS-CoV-2. Therapeutic GS-621763 significantly reduced viral load, lung pathology, and improved pulmonary function in COVID-19 mouse model. The deuterated derivative is called VV116 or Deuremidevir (Cat# 556084 and Cat#333114) | |||
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