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+86 137 2013 4139
| CAS: | 757192-67-9 | Cat No: | JKN00315 | Purity: | 98% |
Note: All products of the company are for scientific research only, and do not provide products and services for any individual
Product Description
| CAS | 757192-67-9 | Cat No | JKN00315 | |
| Name | EN106 | |||
| Synonyms | EN106 | |||
| Smiles | O=C(N(CCC#N)C1=CC=C(OCCO2)C2=C1)CCl | |||
| Chemical Name | 2-chloro-N-(2-cyanoethyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acetamide | |||
| Formula | C13H13ClN2O3 | MWt | 280.708 | |
| Purity | 98% | Storage | Store at 4--8℃ | |
| Description | EN106 is a potent inhibitor of FEMIB. EN106 targets FEM1B, an E3 ligase recently discovered as the critical component of the cellular response to reductive stress. By targeting C186 in FEM1B, EN106 disrupts recognition of the key reductive stress substrate of FEM1B, FNIP1. EN106 can be used as a covalent recruiter for FEM1B in TPD applications by demonstrating that a PROTAC linking EN106 to the BET bromodomain inhibitor JQ1 or the kinase inhibitor dasatinib leads to the degradation of BRD4 and BCR-ABL, respectively. | |||
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