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| CAS: | 254750-02-2 | Cat No: | JKN00191 | Purity: | 98% |
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Product Description
| CAS | 254750-02-2 | Cat No | JKN00191 | |
| Name | Emricasan | |||
| Synonyms | IDN6556 | |||
| Smiles | O=C(O)C[C@H](NC([C@H](C)NC(C(NC1=CC=CC=C1C(C)(C)C)=O)=O)=O)C(COC2=C(F)C(F)=CC(F)=C2F)=O | |||
| Chemical Name | (S)-3-((S)-2-(2-((2-(tert-butyl)phenyl)amino)-2-oxoacetamido)propanamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid | |||
| Formula | C26H27F4N3O7 | MWt | 569.51 | |
| Purity | 98% | Storage | Store at 4--8℃ | |
| Description | Emricasan, also known as IDN 6556 and PF 03491390, is a first-in-class caspase inhibitor in clinical trials for the treatment of liver diseases. Emricasan (IDN-6556) decreases liver injury and fibrosis in a murine model of non-alcoholic steatohepatitis. IDN6556 facilitates marginal mass islet engraftment in a porcine islet autotransplant model. Oral IDN-6556 may lower aminotransferase activity in patients with chronic hepatitis C. Orally-administered PF-03491390 is retained in the liver for prolonged periods with low systemic exposure, exerting a hepatoprotective effect against alpha-fas-induced liver injury in a mouse model. | |||
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