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| CAS: | 1073154-85-4 | Cat No: | JKN00186 | Purity: | 98% |
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Product Description
| CAS | 1073154-85-4 | Cat No | JKN00186 | |
| Name | Defactinib | |||
| Synonyms | VS-6063 | |||
| Smiles | O=C(NC)C1=CC=C(NC2=NC=C(C(F)(F)F)C(NCC3=NC=CN=C3N(C)S(=O)(C)=O)=N2)C=C1 | |||
| Chemical Name | N-methyl-4-((4-(((3-(N-methylmethylsulfonamido)pyrazin-2-yl)methyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzamide | |||
| Formula | C20H21F3N8O3S | MWt | 510.49 | |
| Purity | 98% | Storage | Store at 4--8℃ | |
| Description | Defactinib, also known as VS-6063 and PF-04554878, is an orally bioavailable, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. FAK inhibitor PF-04554878 inhibits FAK, which may prevent the integrin-mediated activation of several downstream signal transduction pathways, including ERK, JNK/MAPK and PI3K/Akt, thus inhibiting tumor cell migration, proliferation and survival. | |||
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