Pharmaceutical intermediates

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CSN5i-3

CAS: 2375740-98-8 Cat No: JKN03387 Purity: 98%

Note: All products of the company are for scientific research only, and do not provide products and services for any individual

Product Description

CAS 2375740-98-8 Cat No JKN03387
Name CSN5i-3
Synonyms CSN5i-3
Smiles CC(C)N1C(=CC(=N1)C(F)F)C(=O)NC2=CC(=C(C=C2)[C@H]3[C@H](CCCC4=CN=CN34)O)C5=CC=CC=C5
Chemical Name 5-(difluoromethyl)-N-[4-[(5S,6S)-6-hydroxy-6,7,8,9-tetrahydro-5H-imidazo[1,5-a]azepin-5-yl]-3-phenylphenyl]-2-propan-2-ylpyrazole-3-carboxamide
Formula C28H29F2N5O2 MWt 505.6
Purity 98% Storage Store at 4--8℃
Description CSN5i-3 is a novel, highly selective and orally bioavailable inhibitor of CSN5/Jab1, inhibiting CSN-catalysed Cul1 deneddylation with an IC50 value of 5.8 nM.

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