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| CAS: | 288262-96-4 | Cat No: | JKN00303 | Purity: | 98% |
Note: All products of the company are for scientific research only, and do not provide products and services for any individual
Product Description
| CAS | 288262-96-4 | Cat No | JKN00303 | |
| Name | BX-471 HCl | |||
| Synonyms | BX-471 | |||
| Smiles | FC1=CC=C(C=C1)CN2C[C@@H](C)N(C(COC3=CC=C(Cl)C=C3NC(N)=O)=O)CC2.[H]Cl | |||
| Chemical Name | (2R)-1-(((4-Chloro-2-(ureido)phenoxy)methyl)carbonyl)-2-methyl-4-(4-fluorobenzyl)piperazine hydrochloride | |||
| Formula | C21H25Cl2FN4O3 | MWt | 471.350 | |
| Purity | 98% | Storage | Store at 4--8℃ | |
| Description | BX-471, also known as ZK-811752, is a potent, selective non-peptide CCR1 antagonist (Ki = 1 nM for human CCR1). BX-471 exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4. BX-471 was developed Berlex and its parent company, Schering AG. BX-471 is the lead in a series of non-peptide chemokine receptor 1 (CCR1) antagonists, for the potential treatment of autoimmune diseases, in particular multiple sclerosis (MS). In March 2000, BX-471 was undergoing phase I trials for the potential treatment of autoimmune diseases. | |||
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