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+86 137 2013 4139
| CAS: | 1990504-72-7 | Cat No: | JKN00176 | Purity: | 98% |
Note: All products of the company are for scientific research only, and do not provide products and services for any individual
Product Description
| CAS | 1990504-72-7 | Cat No | JKN00176 | |
| Name | Bomedemstat ditosylate | |||
| Synonyms | IMG7289 | |||
| Smiles | O=C(N[C@@H](CCCN[C@H]1[C@H](C2=CC=C(F)C=C2)C1)C(N3CCN(C)CC3)=O)C4=CC=C(N5N=NC=C5)C=C4.OS(=O)(C6=CC=C(C)C=C6)=O.OS(=O)(C7=CC=C(C)C=C7)=O | |||
| Chemical Name | N-((2S)-5-(((1R,2S)-2-(4-Fluorophenyl)cyclopropyl)amino)-1-(4-methylpiperazin-1-yl)-1-oxopentan-2-yl)-4-(1H-1,2,3-triazol-1-yl)benzamide bis-tosylate salt | |||
| Formula | 864.021 | MWt | C42H50FN7O8S2 | |
| Purity | 98% | Storage | Store at 4--8℃ | |
| Description | Bomedemstat, also known as IMG-7289 and MK-3543, is a lysine-specific histone demethylase 1 (LSD1) inhibitor with antineoplastic activity. Bomedemstat may be useful in the treatment of acute myeloid leukaemia, myelodysplastic syndrome, and Myelofibrosis. IMG-7289 selectively inhibited proliferation and induced apoptosis of JAK2 V617F cells by concomitantly increasing expression and methylation of p53, and, independently, the pro-apoptotic factor PUMA and by decreasing the levels of its antiapoptotic antagonist BCLXL. | |||
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