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| CAS: | 1118567-05-7 | Cat No: | JKN00306 | Purity: | 98% |
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Product Description
| CAS | 1118567-05-7 | Cat No | JKN00306 | |
| Name | Bexagliflozin | |||
| Synonyms | THR1442 | |||
| Smiles | OC[C@@H](O1)[C@@H](O)[C@H](O)[C@@H](O)C1C2=CC(CC(C=C3)=CC=C3OCCOC4CC4)=C(Cl)C=C2 | |||
| Chemical Name | (3R,4R,5S,6R)-2-(4-chloro-3-(4-(2-cyclopropoxyethoxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol | |||
| Formula | C24H29ClO7 | MWt | 464.940 | |
| Purity | 98% | Storage | Store at 4--8℃ | |
| Description | Bexagliflozin, also known as EGT1442, is a potent and selective SGLT2 inhibitor, attenuates blood glucose and HbA(1c) levels in db/db mice and prolongs the survival of stroke-prone rats. The IC(50) values for EGT1442 against human SGLT1 and SGLT2 are 5.6μM and 2nM, respectively. In normal rats and dogs a saturable urinary glucose excretion was produced with an ED(50) of 0.38 and 0.09mg/kg, respectively. EGT1442 showed favorable properties both in vitro and in vivo and could be beneficial to the management of type 2 diabetic patients. | |||
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