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| CAS: | 213819-48-8 | Cat No: | JKN00544 | Purity: | 98% |
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Product Description
| CAS | 213819-48-8 | Cat No | JKN00544 | |
| Name | Belotecan hydrochloride | |||
| Synonyms | Belotecan hydrochloride | |||
| Smiles | CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C(C5=CC=CC=C5N=C4C3=C2)CCNC(C)C)O.Cl | |||
| Chemical Name | (19S)-19-ethyl-19-hydroxy-10-[2-(propan-2-ylamino)ethyl]-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione;hydrochloride | |||
| Formula | C25H28ClN3O4 | MWt | 470.0 | |
| Purity | 98% | Storage | Store at 4--8℃ | |
| Description | Belotecan Hydrochloride is the hydrochloride salt of the semi-synthetic camptothecin analogue belotecan with potential antitumor activity. Belotecan binds to and inhibits the activity of topoisomerase I, stabilizing the cleavable complex of topoisomerase I-DNA, which inhibits the religation of single-stranded DNA breaks generated by topoisomerase I; lethal double-stranded DNA breaks occur when the topoisomerase I-DNA complex is encountered by the DNA replication machinery, DNA replication is disrupted, and the tumor cell undergoes apoptosis. Topoisomerase I is an enzyme that mediates reversible single-strand breaks in DNA during DNA replication. | |||
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