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| CAS: | 1103522-45-7 | Cat No: | JKN00522 | Purity: | 98% |
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Product Description
| CAS | 1103522-45-7 | Cat No | JKN00522 | |
| Name | Aprocitentan | |||
| Synonyms | Aprocitentan | |||
| Smiles | C1=CC(=CC=C1C2=C(N=CN=C2OCCOC3=NC=C(C=N3)Br)NS(=O)(=O)N)Br | |||
| Chemical Name | 5-(4-bromophenyl)-4-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-6-(sulfamoylamino)pyrimidine | |||
| Formula | C16H14Br2N6O4S | MWt | 546.2 | |
| Purity | 98% | Storage | Store at 4--8℃ | |
| Description | ACT-132577 is a member of the class of sulfamides in which one of the amino groups of sulfonamide is substituted by a 5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl group. An active metabolite of macitentan (obtained by oxidative depropylation), an orphan drug used for the treatment of pulmonary arterial hypertension. It has a role as an antihypertensive agent, an endothelin receptor antagonist, a drug metabolite and a xenobiotic metabolite. It is an aromatic ether, an organobromine compound, a member of pyrimidines and a member of sulfamides. It is functionally related to an ethylene glycol. | |||
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