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+86 137 2013 4139
| CAS: | 2984506-77-4 | Cat No: | JKN00207 | Purity: | 98% |
Note: All products of the company are for scientific research only, and do not provide products and services for any individual
Product Description
| CAS | 2984506-77-4 | Cat No | JKN00207 | |
| Name | AK-2292 | |||
| Synonyms | AK-2292 | |||
| Smiles | FC(P(O)(O)=O)(F)C1=CC2=C(SC(C(N[C@@H](C(C)(C)C)C(N3CCC[C@H]3C(N(C4=CC=C(C5=NC=CS5)C=C4)CCC(N(C)CCCC#CC6=CC=CC7=C6CN(C8C(NC(CC8)=O)=O)C7=O)=O)=O)=O)=O)=C2)C=C1 | |||
| Chemical Name | ((2-(((2S)-1-((2S)-2-((3-((5-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)pent-4-yn-1-yl)(methyl)amino)-3-oxopropyl)(4-(thiazol-2-yl)phenyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)carbamoyl)benzo[b]thiophen-5-yl)difluoromethyl)phosphonic acid | |||
| Formula | C52H54F2N7O10PS2 | MWt | 1,070.130 | |
| Purity | 98% | Storage | Store at 4--8℃ | |
| Description | AK-2292 is a Potent and Selective STAT5 PROTAC Degrader with Strong Antitumor Activity In Vivo in Acute Myeloid Leukemia. AK-2292 effectively induces degradation of STAT5A, STAT5B, and phosphorylated STAT5 proteins in a concentration- and time-dependent manner in acute myeloid leukemia (AML) cell lines and demonstrates excellent degradation selectivity for STAT5 over all other STAT members. It exerts potent and specific cell growth inhibitory activity in AML cell lines with high levels of phosphorylated STAT5. AK-2292 effectively reduces STAT5 protein in vivo and achieves strong antitumor activity in mice at well-tolerated dose schedules. | |||
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